{"id":23518,"date":"2023-06-07T10:13:10","date_gmt":"2023-06-07T02:13:10","guid":{"rendered":"https:\/\/www.cacm.org.cn\/?p=23518"},"modified":"2023-06-07T10:16:57","modified_gmt":"2023-06-07T02:16:57","slug":"2021%e5%b9%b4%e5%ba%a6%e4%b8%ad%e5%8c%bb%e8%8d%af%e5%8d%81%e5%a4%a7%e5%ad%a6%e6%9c%af%e8%bf%9b%e5%b1%95","status":"publish","type":"post","link":"https:\/\/www.cacm.org.cn\/2023\/06\/07\/23518\/","title":{"rendered":"2021\u5e74\u5ea6\u4e2d\u533b\u836f\u5341\u5927\u5b66\u672f\u8fdb\u5c55"},"content":{"rendered":"<p><span style=\"font-family: \u4eff\u5b8b;\">\u00a0 \u00a0 <\/span>\u4e3a\u8d2f\u5f7b\u843d\u5b9e\u300a\u4e2d\u5171\u4e2d\u592e 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style=\"font-family: \u4eff\u5b8b;\">\u00a0 \u00a0 <\/span>\u54c8\u4f5b\u5927\u5b66\u3001\u590d\u65e6\u5927\u5b66\u3001\u4e2d\u56fd\u4e2d\u533b\u79d1\u5b66\u9662\u9488\u7078\u7814\u7a76\u6240\u548c\u798f\u5efa\u4e2d\u533b\u836f\u5927\u5b66\u8054\u5408\u7814\u7a76\u53d1\u73b0\uff0c\u5728\u8113\u6bd2\u8840\u75c7\u7684\u5c0f\u9f20\u6a21\u578b\u4e0a\u7535\u9488\u523a\u6fc0\u5176\u540e\u80a2\u201c\u8db3\u4e09\u91cc\u201d\u7a74\u4f4d\uff08ST36\uff09\uff0c\u53ef\u6fc0\u6d3bPROKR2-Cre\u6807\u8bb0\u7684\u80cc\u6839\u795e\u7ecf\u8282\u611f\u89c9\u795e\u7ecf\u5143\uff0c\u8fd9\u7ec4\u795e\u7ecf\u5143\u53ef\u4ee5\u8c03\u8282\u8ff7\u8d70\u795e\u7ecf-\u80be\u4e0a\u817a\u53cd\u5c04\uff0c\u6291\u5236\u708e\u75c7\u53cd\u5e94\uff0c\u4ece\u800c\u4e3a\u7535\u9488\u7078\u523a\u6fc0\u201c\u8db3\u4e09\u91cc\u201d\u7a74\u4f4d\u53d1\u6325\u5168\u8eab\u6297\u708e\u6548\u679c\u627e\u5230\u4e86\u73b0\u4ee3\u795e\u7ecf\u89e3\u5256\u5b66\u7684\u57fa\u7840\u3002\u8fd9\u4e9b\u53d1\u73b0\u4e0d\u4ec5\u5b9e\u73b0\u4e86\u9488\u7078\u7814\u7a76\u7684\u5386\u53f2\u6027\u7a81\u7834\uff0c\u800c\u4e14\u5145\u5b9e\u4e86\u9488\u7078\u7b49\u4f53\u8868\u523a\u6fc0\u7597\u6cd5\u7684\u73b0\u4ee3\u79d1\u5b66\u5185\u6db5\uff0c\u4e3a\u4e34\u5e8a\u4f18\u5316\u9488\u523a\u523a\u6fc0\u53c2\u6570\uff0c\u8bf1\u53d1\u4e0d\u540c\u81ea\u4e3b\u795e\u7ecf\u53cd\u5c04\uff0c\u4ece\u800c\u6cbb\u7597\u7279\u5b9a\u7684\u75be\u75c5\uff08\u5982\u708e\u75c7\u98ce\u66b4\u7b49\uff09\u63d0\u4f9b\u4e86\u91cd\u8981\u7684\u79d1\u5b66\u4f9d\u636e\u3002\u76f8\u5173\u5b66\u672f\u8bba\u6587\u4e8e2021\u5e7410\u6708\u5728Nature\u53d1\u8868\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>2.<\/strong><strong>\u6e05\u80ba\u6392\u6bd2\u9897\u7c92\u3001\u5316\u6e7f\u8d25\u6bd2\u9897\u7c92\u3001\u5ba3\u80ba\u8d25\u6bd2\u9897\u7c92\u7b49\u4e2d\u836f\u65b0\u836f\u521b\u5236\u53d6\u5f97\u65b0\u8fdb\u5c55<\/strong><\/p>\n<p><span style=\"font-family: \u4eff\u5b8b;\">\u00a0 \u00a0 <\/span>\u5728\u6297\u51fb\u65b0\u51a0\u80ba\u708e\u75ab\u60c5\u8fc7\u7a0b\u4e2d\uff0c\u6d8c\u73b0\u51fa\u4ee5\u6e05\u80ba\u6392\u6bd2\u65b9\u3001\u5316\u6e7f\u8d25\u6bd2\u65b9\u3001\u5ba3\u80ba\u8d25\u6bd2\u65b9\u4e3a\u4ee3\u8868\u7684\u201c\u4e09\u65b9\u201d\uff0c\u4e34\u5e8a\u7597\u6548\u786e\u5207\uff0c\u6709\u6548\u964d\u4f4e\u4e86\u53d1\u75c5\u7387\u3001\u8f6c\u91cd\u7387\u3001\u75c5\u4ea1\u7387\uff0c\u4fc3\u8fdb\u4e86\u6838\u9178\u8f6c\u9634\uff0c\u63d0\u9ad8\u4e86\u6cbb\u6108\u7387\uff0c\u52a0\u5feb\u4e86\u6062\u590d\u671f\u5eb7\u590d\u30022021\u5e743\u67082\u65e5\uff0c\u57fa\u4e8e\u201c\u4e09\u65b9\u201d\u7814\u53d1\u800c\u6210\u7684\u4e2d\u836f\u65b0\u836f\u6e05\u80ba\u6392\u6bd2\u9897\u7c92\u3001\u5316\u6e7f\u8d25\u6bd2\u9897\u7c92\u3001\u5ba3\u80ba\u8d25\u6bd2\u9897\u7c92\uff0c\u83b7\u5f97\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u4e0a\u5e02\u6279\u51c6\u3002\u201c\u4e09\u65b9\u201d\u5747\u662f\u5728\u53e4\u4ee3\u7ecf\u5178\u540d\u65b9\u57fa\u7840\u4e0a\u521b\u65b0\u800c\u6210\uff0c\u5176\u4e0a\u5e02\u4e5f\u5f00\u8f9f\u4e86\u4e2d\u836f\u65b0\u836f\u521b\u5236\u7684\u65b0\u673a\u5236\uff0c\u662f\u4e2d\u533b\u836f\u539f\u521b\u4f18\u52bf\u6210\u679c\u8f6c\u5316\u7684\u5178\u578b\u30022021\u5e74\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u4e86\u517112\u4e2a\u4e2d\u836f\u65b0\u836f\u4e0a\u5e02\uff0c\u8d85\u8fc7\u6b64\u524d5\u5e74\u5ba1\u6279\u603b\u548c\uff0c\u4e2d\u836f\u65b0\u836f\u521b\u5236\u8fce\u6765\u53ef\u559c\u52bf\u5934\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>3.\u201c<\/strong><strong>\u60c5\u5fd7\u81f4\u75c5<\/strong><strong>\u201d<\/strong><strong>\u7406\u8bba\u7684\u751f\u7269\u533b\u5b66\u57fa\u7840\u7814\u7a76\u53d6\u5f97\u65b0\u8fdb\u5c55<\/strong><\/p>\n<p><span style=\"font-family: \u4eff\u5b8b;\">\u00a0 \u00a0 <\/span>\u60c5\u5fd7\u81f4\u75c5\u662f\u4e2d\u533b\u75c5\u56e0\u75c5\u673a\u5b66\u7684\u91cd\u8981\u7ec4\u6210\u90e8\u5206\uff0c\u6307\u56e0\u4e03\u60c5\u5185\u4f24\u5bfc\u81f4\u7684\u810f\u8151\u3001\u9634\u9633\u3001\u6c14\u8840\u5931\u8c03\u800c\u5f15\u53d1\u75be\u75c5\u7684\u8fc7\u7a0b\u3002\u5728\u591a\u9879\u56fd\u5bb6\u81ea\u7136\u79d1\u5b66\u57fa\u91d1\u7684\u6301\u7eed\u8d44\u52a9\u4e0b\uff0c\u66a8\u5357\u5927\u5b66\u4e2d\u533b\u5b66\u9662\/\u836f\u5b66\u9662\u4f55\u84c9\u84c9\u6559\u6388\u56e2\u961f\u8054\u5408\u9648\u5bb6\u65ed\u6559\u6388\u56e2\u961f\u4ece\u201c\u60c5\u5fd7\u5e94\u6fc0\u201d\u589e\u52a0\u75be\u75c5\u201c\u6613\u611f\u6027\u201d\u7684\u521b\u65b0\u89c6\u89d2\u5bf9\u60c5\u5fd7\u81f4\u75c5\u7406\u8bba\u7684\u751f\u7269\u533b\u5b66\u57fa\u7840\u8fdb\u884c\u4e86\u7814\u7a76\uff0c\u5efa\u7acb\u4e86\u591a\u79cd\u7b26\u5408\u4e2d\u533b\u836f\u4f5c\u7528\u7279\u70b9\u7684\u75be\u75c5\u6613\u611f\u7814\u7a76\u6a21\u578b\uff0c\u63ed\u793a\u60c5\u5fd7\u5e94\u6fc0\u7684\u4e3b\u8981\u6548\u5e94\u5206\u5b50\u662f\u5e94\u6fc0\u6fc0\u7d20\u548c\u6c27\u5316\u5206\u5b50\uff0c\u5f15\u8d77\u6548\u5e94\u9776\u6807\u4e0d\u9971\u548c\u78f7\u8102\u7684\u8fc7\u6c27\u5316\uff0c\u4ece\u800c\u589e\u52a0\u5e94\u6fc0\u7ec6\u80de\u8102\u8d28\u8fc7\u6c27\u5316\u6027\u6b7b\u4ea1\u65b9\u5f0f\u7684\u654f\u611f\u6027\uff0c\u89e3\u6790\u4e86\u60c5\u5fd7\u5e94\u6fc0\u589e\u52a0\u5e15\u91d1\u68ee\u75c5\u3001\u4e73\u817a\u764c\u7b49\u75be\u75c5\u6613\u611f\u6027\u7684\u751f\u7269\u533b\u5b66\u57fa\u7840\u3002\u76f8\u5173\u5b66\u672f\u8bba\u6587\u4e8e2021\u5e74\u5728Nat Chem Biol\u3001Cell Death Differ\u548cActa Pharma Sin B\u53d1\u8868\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>4.<\/strong><strong>\u9488\u523a\u6cbb\u7597\u6162\u6027\u524d\u5217\u817a\u708e<\/strong><strong>\/<\/strong><strong>\u6162\u6027\u76c6\u5e95\u75bc\u75db\u7efc\u5408\u5f81\u83b7\u5f97\u9ad8\u8d28\u91cf\u4e34\u5e8a\u7814\u7a76\u8bc1\u636e<\/strong><\/p>\n<p><span style=\"font-family: \u4eff\u5b8b;\">\u00a0 \u00a0 <\/span>\u4e2d\u56fd\u4e2d\u533b\u79d1\u5b66\u9662\u5e7f\u5b89\u95e8\u533b\u9662\u5218\u5fd7\u987a\u6559\u6388\u7814\u7a76\u56e2\u961f\u901a\u8fc7440\u4f8b\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\uff0c\u8bc1\u5b9e\u4e86\u9488\u523a\u80fd\u663e\u8457\u6539\u5584\u4e2d\u91cd\u5ea6\u6162\u6027\u524d\u5217\u817a\u708e\/\u6162\u6027\u76c6\u5e95\u75bc\u75db\u7efc\u5408\u5f81\u60a3\u8005\u7684\u75c7\u72b6\uff0c\u4e34\u5e8a\u6548\u679c\u53ef\u5728\u6cbb\u7597\u7ed3\u675f\u540e\u6301\u7eed\u81f3\u5c11\u534a\u5e74\u3002\u6b64\u9879\u7814\u7a76\u7528\u9ad8\u8d28\u91cf\u7684\u4e34\u5e8a\u7814\u7a76\u8bc1\u636e\u8bc1\u5b9e\u4e86\u9488\u523a\u6cbb\u7597\u6162\u6027\u524d\u5217\u817a\u708e\/\u6162\u6027\u76c6\u5e95\u75bc\u75db\u7efc\u5408\u5f81\u8fd1\u8fdc\u671f\u7597\u6548\u786e\u5207\uff0c\u5b89\u5168\u6027\u597d\u3002\u586b\u8865\u4e86\u56fd\u9645\u9488\u523a\u6cbb\u7597\u6162\u6027\u524d\u5217\u817a\u708e\/\u6162\u6027\u76c6\u5e95\u75bc\u75db\u7efc\u5408\u5f81\u8fdc\u671f\u7597\u6548\u7f3a\u4e4f\u7684\u7a7a\u767d\u3002\u76f8\u5173\u5b66\u672f\u8bba\u6587\u4e8e2021\u5e748\u6708\u5728Annals of Internal Medicine\u53d1\u8868\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>5.<\/strong><strong>\u57fa\u4e8e\u591a\u56fd\u836f\u5178\u7684\u672c\u8349\u57fa\u56e0\u7ec4\u6570\u636e\u5e93\u4e0a\u7ebf<\/strong><\/p>\n<p><span style=\"font-family: \u4eff\u5b8b;\">\u00a0 \u00a0 <\/span>\u4e2d\u56fd\u4e2d\u533b\u79d1\u5b66\u9662\u4e2d\u836f\u7814\u7a76\u6240\u9648\u58eb\u6797\u6559\u6388\u7814\u7a76\u56e2\u961f\u4f9d\u636e\u591a\u56fd\u836f\u5178\u6536\u5f55\u8349\u836f\u7269\u79cd\uff0c\u5b8c\u6210\u672c\u8349\u57fa\u56e0\u7ec4\u6570\u636e\u5e93\u5efa\u8bbe\u5e76\u4e0a\u7ebf\u3002\u8be5\u6570\u636e\u5e93\u4f9d\u636e\u4e2d\u534e\u4eba\u6c11\u5171\u548c\u56fd\u836f\u5178\u3001\u7f8e\u56fd\u8349\u836f\u5178\u3001\u65e5\u672c\u836f\u5c40\u65b9\u3001\u97e9\u56fd\u836f\u5178\u3001\u5370\u5ea6\u836f\u5178\u3001\u57c3\u53ca\u836f\u5178\u3001\u6b27\u6d32\u836f\u5178\u4ee5\u53ca\u5df4\u897f\u836f\u5178\u7b49\u6536\u5f55903\u4e2a\u8349\u836f\u7269\u79cd\u768434,346\u6761\u6570\u636e\uff0c\u5305\u62ec867\u4e2a\u7269\u79cd\u768421,872\u6761DNA\u6761\u5f62\u7801\u6570\u636e\uff0c674\u4e2a\u7269\u79cd\u76842,203\u4e2a\u7ec6\u80de\u5668\u57fa\u56e0\u7ec4\u4ee5\u53ca49\u4e2a\u7269\u79cd\u768455\u4e2a\u5168\u57fa\u56e0\u7ec4\u6570\u636e\u7b49\u3002\u8be5\u6570\u636e\u5e93\u662f\u5168\u7403\u9996\u4e2a\u9488\u5bf9\u836f\u5178\u6536\u8f7d\u8349\u836f\u7269\u79cd\u7684\u5927\u578b\u57fa\u56e0\u7ec4\u5b66\u6570\u636e\u5e93\uff0c\u5c06\u4e3a\u8349\u836f\u7269\u79cd\u9274\u5b9a\u3001\u7528\u836f\u5b89\u5168\u3001\u836f\u6548\u6210\u5206\u751f\u7269\u5408\u6210\u9014\u5f84\u89e3\u6790\u3001\u4f18\u826f\u54c1\u79cd\u5206\u5b50\u80b2\u79cd\u7b49\u65b9\u9762\u63d0\u4f9b\u4fe1\u606f\u652f\u6491\u3002\u76f8\u5173\u8bba\u6587\u4e8e2021\u5e746\u6708\u5728Science China-Life Sciences\u53d1\u8868\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>6.<\/strong><strong>\u751f\u7269\u4f20\u611f<\/strong><strong>AI<\/strong><strong>\u7b97\u6cd5\u878d\u5408\u7684\u4e2d\u533b\u8fc7\u654f<\/strong><strong>\/<\/strong><strong>\u5e73\u548c\u4f53\u8d28\u5dee\u5f02\u9776\u70b9\u79d1\u5b66\u89e3\u7801<\/strong><\/p>\n<p><span style=\"font-family: \u4eff\u5b8b;\">\u00a0 \u00a0 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