{"id":23526,"date":"2023-06-07T10:21:36","date_gmt":"2023-06-07T02:21:36","guid":{"rendered":"https:\/\/www.cacm.org.cn\/?p=23526"},"modified":"2023-06-07T10:42:19","modified_gmt":"2023-06-07T02:42:19","slug":"2022%e5%b9%b4%e5%ba%a6%e4%b8%ad%e5%8c%bb%e8%8d%af%e5%8d%81%e5%a4%a7%e5%ad%a6%e6%9c%af%e8%bf%9b%e5%b1%95","status":"publish","type":"post","link":"https:\/\/www.cacm.org.cn\/2023\/06\/07\/23526\/","title":{"rendered":"2022\u5e74\u5ea6\u4e2d\u533b\u836f\u5341\u5927\u5b66\u672f\u8fdb\u5c55"},"content":{"rendered":"<p><span style=\"font-family: \u4eff\u5b8b;\">\u00a0 \u00a0 <\/span>\u4e3a\u8d2f\u5f7b\u843d\u5b9e\u515a\u7684\u4e8c\u5341\u5927\u7cbe\u795e\u548c\u300a\u4e2d\u5171\u4e2d\u592e \u56fd\u52a1\u9662\u5173\u4e8e\u4fc3\u8fdb\u4e2d\u533b\u836f\u4f20\u627f\u521b\u65b0\u53d1\u5c55\u7684\u610f\u89c1\u300b\uff0c\u5b9a\u671f\u68b3\u7406\u603b\u7ed3\u4e2d\u533b\u836f\u7814\u7a76\u6210\u679c\uff0c\u52a8\u6001\u5448\u73b0\u4e2d\u533b\u836f\u5b66\u672f\u8fdb\u5c55\uff0c\u5145\u5206\u53d1\u6325\u5b66\u672f\u56e2\u4f53\u7684\u5b66\u672f\u5f15\u9886\u4f5c\u7528\uff0c\u4e2d\u534e\u4e2d\u533b\u836f\u5b66\u4f1a\u7ec4\u7ec7\u5f00\u5c55\u4e86 2022 \u5e74\u5ea6\u4e2d\u533b\u836f\u5341\u5927\u5b66\u672f\u8fdb\u5c55\u9074\u9009\u5de5\u4f5c\u3002<strong>\u672c\u5e74\u5ea6\u9074\u9009\u5de5\u4f5c\u575a\u6301<\/strong><strong>\u201c<\/strong><strong>\u56db\u4e2a\u9762\u5411<\/strong><strong>\u201d<\/strong><strong>\uff0c\u7834\u9664<\/strong><strong>\u201c<\/strong><strong>\u56db\u552f<\/strong><strong>\u201d<\/strong><strong>\uff0c\u7a81\u51fa\u89e3\u51b3\u4e34\u5e8a\u95ee\u9898\u3001\u56de\u7b54\u79d1\u5b66\u95ee\u9898\u3001\u5f15\u9886\u884c\u4e1a\u53d1\u5c55\uff0c\u4f53\u73b0\u63a2\u7d22\u6027\u4e0e\u524d\u77bb\u6027\u3001\u521b\u65b0\u6027\u4e0e\u7a81\u7834\u6027\uff0c<\/strong>\u805a\u7126\u4e2d\u533b\u836f\u57fa\u7840\u7814\u7a76\u548c\u5e94\u7528\u57fa\u7840\u7814\u7a76\u9886\u57df\u53d6\u5f97\u7684\u65b0\u89c4\u5f8b\u3001\u65b0\u53d1\u73b0\u3001\u65b0\u65b9\u6cd5\u3001\u65b0\u4ea7\u54c1\u3001\u65b0\u7406\u8bba\u3002\u7ecf\u52a8\u6001\u6536\u96c6\u3001\u521d\u5ba1\u3001\u590d\u5ba1\u3001\u7ec8\u5ba1\u7b49\u5de5\u4f5c\u7a0b\u5e8f\uff0c\u786e\u5b9a 2022 \u5e74\u5ea6\u4e2d\u533b\u836f\u5341\u5927\u5b66\u672f\u8fdb\u5c55\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u4e00\u3001\u91d1\u82b1\u6e05\u611f\u9897\u7c92\u3001\u758f\u98ce\u89e3\u6bd2\u80f6\u56ca\u3001\u8346\u94f6\u56fa\u8868\u65b9\u7b49\u4e2d\u533b\u836f\u6cbb\u7597\u65b0\u51a0\u75c5\u6bd2\u611f\u67d3\u4e34\u5e8a\u7814\u7a76\u53d6\u5f97\u65b0\u8fdb\u5c55<\/strong><\/p>\n<p><span style=\"font-family: \u4eff\u5b8b;\">\u00a0 \u00a0 <\/span>\u9996\u90fd\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u5317\u4eac\u4e2d\u533b\u533b\u9662\u5218\u6e05\u6cc9\u6559\u6388\u56e2\u961f\u8054\u5408\u5df4\u57fa\u65af\u5766\u5361\u62c9\u5947\u5927\u5b66\u3001\u9999\u6e2f\u6d78\u4f1a\u5927\u5b66\u7b49\u56e2\u961f\uff0c\u5728\u5df4\u57fa\u65af\u5766\u5f00\u5c55\u4e86\u91d1\u82b1\u6e05\u611f\u9897\u7c92\u6cbb\u7597\u65b0\u51a0\u75c5\u6bd2\u611f\u67d3\u7684\u591a\u4e2d\u5fc3\u3001\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u4e34\u5e8a\u7814\u7a76\uff0c\u8bc1\u5b9e\u91d1\u82b1\u6e05\u611f\u9897\u7c92\u6cbb\u7597\u65b0\u51a0\u75c5\u6bd2\u611f\u67d3\u53ef\u663e\u8457\u63d0\u9ad8\u4e34\u5e8a\u6709\u6548\u7387\uff0c\u964d\u4f4e\u8f6c\u91cd\u98ce\u9669\uff0c\u7f29\u77ed\u5355\u9879\u75c7\u72b6\u7f13\u89e3\u65f6\u95f4\u3002\u7814\u7a76\u8bba\u65872022\u5e74\u53d1\u8868\u4e8e<strong><em>Frontiers in Medicine<\/em><\/strong>\u3002<\/p>\n<p><span style=\"font-family: \u4eff\u5b8b;\">\u00a0 \u00a0 <\/span>\u5b89\u5fbd\u4e2d\u533b\u836f\u5927\u5b66\u7b2c\u4e00\u9644\u5c5e\u533b\u9662\u6768\u6587\u660e\u6559\u6388\u56e2\u961f\u7275\u5934\u5f00\u5c55\u758f\u98ce\u89e3\u6bd2\u80f6\u56ca\u6cbb\u7597\u5965\u5bc6\u514b\u620e\u53d8\u5f02\u682a\u611f\u67d3\u4e34\u5e8a\u7814\u7a76\uff0c\u8bc1\u5b9e\u758f\u98ce\u89e3\u6bd2\u80f6\u56ca\u80fd\u663e\u8457\u6539\u5584\u5965\u5bc6\u514b\u620e\u611f\u67d3\u7684\u4e34\u5e8a\u75c7\u72b6\uff0c\u6709\u6548\u7f29\u77ed\u75c7\u72b6\u6301\u7eed\u65f6\u95f4\uff0c\u964d\u4f4e\u8f6c\u91cd\u7387\uff0c\u63d0\u9ad8\u6cbb\u6108\u7387\uff0c\u7f29\u77ed\u6838\u9178\u8f6c\u9634\u65f6\u95f4\u3002\u7814\u7a76\u8bba\u65872022\u5e74\u53d1\u8868\u4e8e<strong><em>BioSci. Trends<\/em><\/strong>\u3002<\/p>\n<p><span style=\"font-family: \u4eff\u5b8b;\">\u00a0 \u00a0 <\/span>\u4e0a\u6d77\u4e2d\u533b\u836f\u5927\u5b66\u9644\u5c5e\u66d9\u5149\u533b\u9662\u9ad8\u6708\u6c42\u6559\u6388\u56e2\u961f\u5f00\u5c55\u8346\u94f6\u56fa\u8868\u65b9\u6539\u5584\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u611f\u67d3\u8f7b\u75c7\u60a3\u8005\u7684\u968f\u673a\u53cc\u76f2\u5bf9\u7167\u8bd5\u9a8c\uff0c\u8bc1\u5b9e\u8346\u94f6\u56fa\u8868\u65b9\u53ef\u63d0\u9ad8\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u611f\u67d3\u8f7b\u75c7\u60a3\u8005\u7684\u6838\u9178\u8f6c\u9634\u7387\uff0c\u7f29\u77ed\u6838\u9178\u8f6c\u9634\u65f6\u95f4\u53ca\u4f4f\u9662\u65f6\u95f4\u3002\u7814\u7a76\u8bba\u65872022\u5e74\u53d1\u8868\u4e8e<strong><em>Int. J. Biol. Sci<\/em><\/strong>\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u4e8c\u3001\u4e2d\u6cd5\u56fd\u9645\u5408\u4f5c\u4e34\u5e8a\u7814\u7a76\u2014\u2014\u9ec4\u8475\u80f6\u56ca\u6cbb\u7597\u7cd6\u5c3f\u75c5\u80be\u75c5\u86cb\u767d\u5c3f\u83b7\u5f97\u9ad8\u8d28\u91cf\u8bc1\u636e<\/strong><\/p>\n<p><span style=\"font-family: \u4eff\u5b8b;\">\u00a0 \u00a0 <\/span>\u5357\u4eac\u4e2d\u533b\u836f\u5927\u5b66\u9644\u5c5e\u533b\u9662\uff08\u6c5f\u82cf\u7701\u4e2d\u533b\u9662\uff09\u5b59\u4f1f\u6559\u6388\u56e2\u961f\u8054\u5408\u6cd5\u56fd\u5df4\u9ece\u516c\u7acb\u533b\u9662\u96c6\u56e2\u6bd4\u63d0\u8036-\u8428\u52d2\u4f2f\u7279\u533b\u9662\u4f0a\u838e\u8d1d\u62c9\u56e2\u961f\u5171\u540c\u5f00\u5c55\u201c\u9ec4\u8475\u80f6\u56ca\u6cbb\u7597\u7cd6\u5c3f\u75c5\u80be\u75c5 (DKD)\u86cb\u767d\u5c3f\u7684\u591a\u4e2d\u5fc3\u3001\u53cc\u76f2\u53cc\u6a21\u62df\u3001\u968f\u673a\u5bf9\u7167\u4e34\u5e8a\u8bd5\u9a8c\u201d\uff0c\u7ed3\u679c\u663e\u793a\u5bf9\u4e8e DKD \u60a3\u8005 ACR \u7684\u7597\u6548\uff0c\u9ec4\u8475\u80f6\u56ca\u4e0e\u5384\u8d1d\u6c99\u5766\u4f5c\u7528\u76f8\u5f53\u4e14\u66f4\u5177\u4f18\u52bf\uff0c\u4e24\u8005\u8054\u5408\u7528\u836f\u7597\u6548\u66f4\u52a0\u663e\u8457\uff0c\u4e3aDKD\u86cb\u767d\u5c3f\u60a3\u8005\u63d0\u4f9b\u4e86\u4e00\u79cd\u65b0\u7684\u6cbb\u7597\u65b9\u6848\u3002\u7814\u7a76\u8bba\u65872022\u5e74\u53d1\u8868\u4e8e<strong><em>Diabetes Care<\/em><\/strong>\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u4e09\u3001\u5faa\u8bc1\u65b9\u6cd5\u652f\u6491\u9488\u7078\u4e34\u5e8a\u7814\u7a76\u53d6\u5f97\u65b0\u8fdb\u5c55<\/strong><\/p>\n<p><span style=\"font-family: \u4eff\u5b8b;\">\u00a0 \u00a0 <\/span>\u4e2d\u56fd\u4e2d\u533b\u79d1\u5b66\u9662\u3001\u4e2d\u56fd\u4e2d\u533b\u79d1\u5b66\u9662\u9488\u7078\u7814\u7a76\u6240\u3001\u4e2d\u56fd\u4e2d\u533b\u836f\u5faa\u8bc1\u533b\u5b66\u4e2d\u5fc3\u3001\u5317\u4eac\u4e2d\u533b\u836f\u5927\u5b66\u5faa\u8bc1\u533b\u5b66\u4e2d\u5fc3\u3001\u5e7f\u5dde\u4e2d\u533b\u836f\u5927\u5b66\u7b49\u56fd\u5185\u7814\u7a76\u56e2\u961f\uff0c\u8054\u5408\u52a0\u62ff\u5927\u3001\u745e\u58eb\u3001\u7f8e\u56fd\u7b499\u4e2a\u56fd\u5bb648\u5bb6\u5355\u4f4d\u7684109\u4f4d\u56fd\u5185\u5916\u4e2d\u897f\u533b\u4e34\u5e8a\u4e13\u5bb6\u3001\u5faa\u8bc1\u533b\u5b66\u4e13\u5bb6\u3001\u6d41\u884c\u75c5\u4e0e\u7edf\u8ba1\u5b66\u4e13\u5bb6\u3001\u4e34\u5e8a\u6307\u5357\u4e13\u5bb6\u3001\u536b\u751f\u7ecf\u6d4e\u5b66\u548c\u536b\u751f\u653f\u7b56\u4e13\u5bb6\u5171\u540c\u53c2\u4e0e\uff0c\u5bf9\u76ee\u524d\u9488\u7078\u968f\u673a\u5bf9\u7167\u4e34\u5e8a\u8bd5\u9a8c\u3001\u7cfb\u7edf\u8bc4\u4ef7\u3001\u4e34\u5e8a\u5b9e\u8df5\u6307\u5357\u53ca\u536b\u751f\u7ecf\u6d4e\u5b66\u7814\u7a76\u7684\u73b0\u72b6\u548c\u8d28\u91cf\u8fdb\u884c\u8bc4\u4ef7\uff0c\u5e76\u63d0\u51fa\u65b9\u6cd5\u5b66\u5efa\u8bae\uff0c\u5f62\u6210\u4e13\u5bb6\u5171\u8bc6\u3002\u7cfb\u5217\u7814\u7a76\u8bba\u65872022\u5e74\u4ee5\u4e13\u8f91\u5f62\u5f0f\u53d1\u8868\u4e8e<strong><em>Br. Med. J.<\/em><\/strong>\u3002<\/p>\n<p><span style=\"font-family: \u4eff\u5b8b;\">\u00a0 \u00a0 <\/span>\u5317\u4eac\u4e2d\u533b\u836f\u5927\u5b66\u5218\u5b58\u5fd7\u6559\u6388\u56e2\u961f\u3001\u4e0a\u6d77\u4e2d\u533b\u836f\u5927\u5b66\u9644\u5c5e\u5e02\u4e2d\u533b\u533b\u9662\u5f90\u4e16\u82ac\u6559\u6388\u56e2\u961f\u3001\u6210\u90fd\u4e2d\u533b\u836f\u5927\u5b66\u674e\u745b\u6559\u6388\u548c\u90d1\u6656\u6559\u6388\u56e2\u961f\u5206\u522b\u5f00\u5c55\u9488\u523a\u4fc3\u8fdb\u672f\u540e\u80c3\u80a0\u529f\u80fd\u6062\u590d\u3001\u7535\u9488\u6cbb\u7597\u6291\u90c1\u75c7\u5931\u7720\u3001\u9488\u523a\u6cbb\u7597\u6162\u6027\u7d27\u5f20\u578b\u5934\u75db\u4e34\u5e8a\u7814\u7a76\uff0c\u83b7\u5f97\u9ad8\u8d28\u91cf\u4e34\u5e8a\u8bc1\u636e\u3002\u76f8\u5173\u7814\u7a76\u8bba\u65872022\u5e74\u5206\u522b\u53d1\u8868\u4e8e<strong><em>EClinicalMedicine, JAMA Surg., JAMA Network Open, Neurology<\/em><\/strong>\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u56db\u3001\u4e2d\u533b\u836f\u6cbb\u7597\u514b\u7f57\u6069\u75c5\u7b49\u6162\u6027\u96be\u6cbb\u6027\u75be\u75c5\u83b7\u5f97\u65b0\u8bc1\u636e<\/strong><\/p>\n<p><span style=\"font-family: \u4eff\u5b8b;\">\u00a0 \u00a0 <\/span>\u4e0a\u6d77\u4e2d\u533b\u836f\u5927\u5b66\u5434\u7115\u6de6\u6559\u6388\u548c\u5b63\u5149\u6559\u6388\u56e2\u961f\u7ec4\u7ec7\u5f00\u5c55\u9488\u7078\u3001\u7ecf\u65b9\u4e34\u5e8a\u7814\u7a76\uff0c\u8bc1\u5b9e\u9488\u7078\u5bf9\u836f\u7269\u4e0d\u54cd\u5e94\u7684\u8f7b\u4e2d\u5ea6\u6d3b\u52a8\u6027\u514b\u7f57\u6069\u75c5\u60a3\u8005\u5b89\u5168\u6709\u6548\uff1b\u8bc1\u5b9e\u4f4e\u5242\u91cf\u82d3\u6842\u672f\u7518\u6c64\u53ef\u663e\u8457\u6539\u5584\u80a5\u80d6\u578b\u8102\u80aa\u809d\u813e\u9633\u865a\u8bc1\u60a3\u8005\u7684HOMA-IR\u5e76\u53d1\u73b0\u5176\u836f\u6548\u7269\u8d28\u57fa\u7840\uff1b\u8bc1\u5b9e\u7a74\u4f4d\u57cb\u7ebf\u7597\u6cd5\u51cf\u8f7b\u80a5\u80d6\u60a3\u8005\u4f53\u91cd\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002\u76f8\u5173\u7814\u7a76\u8bba\u65872022\u5e74\u53d1\u8868\u4e8e<strong><em>EClinicalMedicine, Front. Med., Front. Endocrinol.<\/em><\/strong>\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u4e94\u3001\u5355\u7ec6\u80de\u7ec4\u5b66\u3001\u9776\u70b9\u201c\u94a9\u9493\u201d\u7b49\u65b0\u6280\u672f\u52a9\u529b\u4e2d\u836f\u529f\u6548\u79d1\u5b66\u5185\u6db5\u9610\u91ca<\/strong><\/p>\n<p><span style=\"font-family: \u4eff\u5b8b;\">\u00a0 \u00a0 <\/span>\u6d59\u6c5f\u5927\u5b66\u8303\u9a81\u8f89\u6559\u6388\u548c\u738b\u6bc5\u6559\u6388\u56e2\u961f\uff0c\u4ee5\u4e39\u53c2\u3001\u7ea2\u666f\u5929\u7b49\u6d3b\u8840\u7c7b\u4e2d\u836f\u4e3a\u5bf9\u8c61\uff0c\u9488\u5bf9\u7cfb\u7edf\u89e3\u6790\u4e2d\u836f\u6cbb\u75c5\u79d1\u5b66\u539f\u7406\u7684\u6280\u672f\u74f6\u9888\u5f00\u53d1\u4e86SpaTalk\u3001Bulk2Space\u7b49\u7cfb\u5217\u5355\u7ec6\u80de\u7ec4\u5b66\u5206\u6790\u65b0\u5de5\u5177\uff0c\u53d1\u73b0\u514d\u75ab\u7ec6\u80de\u5bf9\u5fc3\u6897\u540e\u635f\u4f24\u4fee\u590d\u8fc7\u7a0b\u7684\u52a8\u6001\u8c03\u63a7\u4f5c\u7528\uff0c\u8be0\u91ca\u4e86\u4e39\u53c2\u916eIIA\u8c03\u63a7\u514d\u75ab\u7ec6\u80de\u4e9a\u7fa4\u51cf\u5c11\u5fc3\u808c\u6897\u6b7b\u8303\u56f4\u3001\u7ea2\u666f\u5929\u4e2d\u8349\u8d28\u7d20\u6291\u5236SGK1\u6297\u5fc3\u808c\u80a5\u5927\u7684\u4f5c\u7528\u673a\u5236\u3002\u7814\u7a76\u8bba\u65872022\u5e74\u53d1\u8868\u4e8e <strong><em>Nat. Commun., Adv. Sci., Small methods<\/em><\/strong>\u7b49\uff0c\u5e76\u83b7\u6388\u6743\u53d1\u660e\u4e13\u52293\u9879\u3002<\/p>\n<p><span style=\"font-family: \u4eff\u5b8b;\">\u00a0 \u00a0 <\/span>\u5317\u4eac\u5927\u5b66\u533b\u5b66\u90e8\u66fe\u514b\u6b66\u6559\u6388\u548c\u5c60\u9e4f\u98de\u6559\u6388\u56e2\u961f\u4ee5\u4e2d\u836f\u836f\u6548\u6210\u5206\u4e3a\u5de5\u5177\u63a2\u9488\uff0c\u901a\u8fc7\u9776\u70b9\u201c\u94a9\u9493\u201d\u6280\u672f\u7cfb\u7edf\u63ed\u793a\u4e86\u87fe\u9165\u3001\u4e94\u5473\u5b50\u3001\u91ce\u9a6c\u8ffd\u7b49\u4e2d\u836f\u4ee3\u8868\u6027\u6210\u5206\u7684\u76f4\u63a5\u9776\u70b9\u86cb\u767d\u53ca\u53c2\u4e0e\u75be\u75c5\u76f8\u5173\u8fdb\u7a0b\u7684\u5206\u5b50\u751f\u7269\u5b66\u673a\u5236\uff0c\u4e3a\u201c\u6e05\u70ed\u89e3\u6bd2\u3001\u8865\u80be\u5b81\u5fc3\u3001\u6d88\u80bf\u5229\u6e7f\u201d\u7b49\u4e2d\u836f\u529f\u6548\u63d0\u4f9b\u4e86\u5fae\u89c2\u8bc1\u636e\uff0c\u540c\u65f6\u4e5f\u63d0\u51fa\u4e86\u5177\u5907\u81ea\u4e3b\u77e5\u8bc6\u4ea7\u6743\u7684\u514d\u75ab\u708e\u75c7\u3001\u80bf\u7624\u3001\u795e\u7ecf\u9000\u884c\u7b49\u91cd\u5927\u75be\u75c5\u6cbb\u7597\u65b0\u9776\u70b9\u3002\u7814\u7a76\u8bba\u65872022\u5e74\u53d1\u8868\u4e8e<strong><em>Sci. Adv., EBioMedicine<\/em><\/strong>\u7b49\u3002<\/p>\n<p><span style=\"font-family: \u4eff\u5b8b;\">\u00a0 \u00a0 <\/span>\u535a\u5965\u751f\u7269\u96c6\u56e2\u6709\u9650\u516c\u53f8\u3001\u5317\u4eac\u535a\u5965\u6676\u65b9\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8\u7814\u7a76\u56e2\u961f\u5229\u7528\u201c\u8d85\u5927\u89c4\u6a21\u7684\u4e2d\u836f\u5206\u5b50\u529f\u80fd\u57fa\u56e0\u8868\u8fbe\u8c31\u6570\u636e\u5e93\u201d\uff0c\u7b5b\u9009\u51fa\u591a\u79cd\u5177\u6709\u8c03\u8282\u8840\u8102\u3001\u8840\u7cd6\u529f\u6548\u7684\u5929\u7136\u690d\u7269\uff0c\u5e76\u5229\u7528\u591a\u7ec4\u5b66\u6280\u672f\u7cfb\u7edf\u5206\u6790\u51fa\u9ebb\u7af9\u964d\u8840\u7cd6\u7684\u4f5c\u7528\u673a\u7406\u548c\u836f\u6548\u7269\u8d28\u57fa\u7840\u3002\u7814\u7a76\u8bba\u65872022\u5e74\u53d1\u8868\u4e8e<strong><em>Acta Pharm. Sin. B<\/em><\/strong>\u3002<\/p>\n<p><span style=\"font-family: \u4eff\u5b8b;\">\u00a0 \u00a0 <\/span>\u5927\u8fde\u533b\u79d1\u5927\u5b66\u9a6c\u9a81\u9a70\u6559\u6388\u56e2\u961f\u63d0\u51fa\u5206\u5b50\u62fc\u63a5\u7b49\u5316\u5b66\u751f\u7269\u5b66\u65b0\u7b56\u7565\uff0c\u5b9e\u73b0\u4ee3\u8c22\u9176\u3001\u80a0\u9053\u83cc\u7b49\u708e\u75c7\u4ee3\u8c22\u9776\u70b9\u7684\u591a\u7ef4\u5ea6\u5b9e\u65f6\u3001\u5b9a\u91cf\u68c0\u6d4b\u4e0e\u8bc6\u522b\uff0c\u8be0\u91ca\u90e8\u5206\u5e38\u7528\u4e2d\u836f\u53d1\u6325\u6297\u708e\u529f\u6548\u7684\u7269\u8d28\u57fa\u7840\u548c\u6f5c\u5728\u5206\u5b50\u673a\u5236\uff0c\u4e3a\u9610\u660e\u4e2d\u533b\u836f\u79d1\u5b66\u5185\u6db5\u63d0\u4f9b\u4e86\u6709\u6548\u7684\u65b9\u6cd5\u4e0e\u5de5\u5177\u3002\u76f8\u5173\u7814\u7a76\u8bba\u65872022\u5e74\u53d1\u8868\u4e8e<strong><em>Signal Transduction Targeted Ther., PNAS, Gut, Angew. Chem., Int. Ed., Nat. Prod. Rep., J. Adv. Res., Acta Pharm. Sin. B, ACS Sens., Anal. Chem.<\/em><\/strong>\uff0c\u5e76\u83b7\u6388\u6743\u53d1\u660e\u4e13\u522910\u9879\uff0c\u5f00\u53d16\u79cd\u68c0\u6d4b\u8bd5\u5242\u76d2\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u516d\u3001\u9752\u84bf\u539f\u690d\u7269\u9ec4\u82b1\u84bf\u9996\u4e2a\u67d3\u8272\u4f53\u7ea7\u522b\u57fa\u56e0\u7ec4\u56fe\u8c31\u7834\u89e3<\/strong><\/p>\n<p><span style=\"font-family: \u4eff\u5b8b;\">\u00a0 \u00a0 <\/span>\u9648\u58eb\u6797\u6559\u6388\u7814\u7a76\u56e2\u961f\u8054\u5408\u4e2d\u56fd\u4e2d\u533b\u79d1\u5b66\u9662\u3001\u6210\u90fd\u4e2d\u533b\u836f\u5927\u5b66\u3001\u5929\u6d25\u4e2d\u533b\u836f\u5927\u5b66\u3001\u5e7f\u4e1c\u7701\u4e2d\u533b\u9662\u7b49\u56e2\u961f\uff0c\u6784\u5efa\u5e76\u516c\u5e03\u4e86\u9ec4\u82b1\u84bf\u9996\u4e2a\u67d3\u8272\u4f53\u7ea7\u522b\u5206\u578b\u57fa\u56e0\u7ec4\u56fe\u8c31\u3002\u9879\u76ee\u56e2\u961f\u901a\u8fc7\u57fa\u56e0\u7ec4\u5206\u6790\u63ed\u793a\u4e86\u9752\u84bf\u7d20\u542b\u91cf\u4e0e\u7d2b\u7a57\u69d0\u4e8c\u70ef\u5408\u9176\u57fa\u56e0\u62f7\u8d1d\u6570\u4e4b\u95f4\u7684\u76f8\u5173\u6027\uff0c\u4e3a\u9752\u84bf\u7d20\u751f\u7269\u5408\u6210\u53ca\u8c03\u63a7\u3001\u9ec4\u82b1\u84bf\u4f18\u826f\u54c1\u79cd\u9009\u80b2\u63d0\u4f9b\u4e86\u66f4\u52a0\u51c6\u786e\u548c\u5168\u9762\u7684\u9057\u4f20\u80cc\u666f\uff0c\u8be5\u53d1\u73b0\u6709\u5229\u4e8e\u9ad8\u9752\u84bf\u7d20\u542b\u91cf\u7684\u9ec4\u82b1\u84bf\u9009\u80b2\u3002\u7814\u7a76\u8bba\u65872022\u5e74\u53d1\u8868\u4e8e<strong><em>Mol. Plant<\/em><\/strong><strong><em>\u3002<\/em><\/strong><\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u4e03\u3001\u9996\u4e2a\u6309\u53e4\u4ee3\u7ecf\u5178\u540d\u65b9\u76ee\u5f55\u7ba1\u7406\u7684\u4e2d\u836f\uff08\u82d3\u6842\u672f\u7518\u9897\u7c92\uff09\u83b7\u6279\u4e0a\u5e02<\/strong><\/p>\n<p><span style=\"font-family: \u4eff\u5b8b;\">\u00a0 \u00a0 <\/span>2022\u5e7412\u670827\u65e5\uff0c\u9996\u4e2a\u6309\u53e4\u4ee3\u7ecf\u5178\u540d\u65b9\u76ee\u5f55\u7ba1\u7406\u7684\u4e2d\u836f\u590d\u65b9\u5236\u5242\uff08\u5373\u4e2d\u836f3.1\u7c7b\u65b0\u836f\uff09\u82d3\u6842\u672f\u7518\u9897\u7c92\u901a\u8fc7\u6280\u672f\u5ba1\u8bc4\uff0c\u83b7\u6279\u4e0a\u5e02\u3002\u8be5\u836f\u54c1\u5904\u65b9\u6765\u6e90\u4e8e\u6c49\u00b7\u5f20\u4ef2\u666f\u300a\u91d1\u532e\u8981\u7565\u300b\uff0c\u5df2\u5217\u5165\u300a\u53e4\u4ee3\u7ecf\u5178\u540d\u65b9\u76ee\u5f55\uff08\u7b2c\u4e00\u6279\uff09\u300b\u3002\u6c5f\u82cf\u5eb7\u7f18\u836f\u4e1a\u80a1\u4efd\u6709\u9650\u516c\u53f8\u8096\u4f1f\u6559\u6388\u56e2\u961f\u548c\u4e0a\u6d77\u4e2d\u533b\u836f\u5927\u5b66\u5b63\u5149\u6559\u6388\u56e2\u961f\u5bf9\u82d3\u6842\u672f\u7518\u6c64\u5386\u4ee3\u533b\u7c4d\u3001\u533b\u6848\u8fdb\u884c\u7cfb\u7edf\u68b3\u7406\uff0c\u660e\u786e\u4e86\u5173\u952e\u4fe1\u606f\uff1b\u5b8c\u6210\u4e86\u836f\u6750\u57fa\u539f\u3001\u836f\u7528\u90e8\u4f4d\u3001\u996e\u7247\u70ae\u5236\u3001\u57fa\u51c6\u6837\u54c1\u3001\u5236\u5242\u5de5\u827a\u7b49\u7cfb\u7edf\u7814\u7a76\uff0c\u5efa\u7acb\u4e86\u7b26\u5408\u4e2d\u836f\u7279\u70b9\u7684\u5168\u8fc7\u7a0b\u3001\u591a\u7ef4\u5ea6\u7684\u8d28\u91cf\u63a7\u5236\u4f53\u7cfb\uff0c\u4fdd\u969c\u5236\u5242\u8d28\u91cf\u7a33\u5b9a\u3001\u53ef\u63a7\u3002\u82d3\u6842\u672f\u7518\u9897\u7c92\u7684\u4e0a\u5e02\u662f\u6df1\u5165\u53d1\u6398\u4e2d\u533b\u836f\u5b9d\u5e93\u7cbe\u534e\uff0c\u63a8\u8fdb\u53e4\u4ee3\u7ecf\u5178\u540d\u65b9\u5411\u65b0\u836f\u8f6c\u5316\u7684\u4e00\u6b21\u751f\u52a8\u5b9e\u8df5\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u516b\u3001\u5b66\u672f\u7814\u7a76\u52a9\u529b\u201c\u4e09\u7ed3\u5408\u201d\u4e2d\u836f\u6ce8\u518c\u5ba1\u8bc4\u8bc1\u636e\u4f53\u7cfb\u6784\u5efa<\/strong><\/p>\n<p><span style=\"font-family: \u4eff\u5b8b;\">\u00a0 \u00a0 <\/span>\u4e3a\u63a8\u52a8\u4e2d\u533b\u836f\u7406\u8bba\u3001\u4eba\u7528\u7ecf\u9a8c\u548c\u4e34\u5e8a\u8bd5\u9a8c\u76f8\u7ed3\u5408\u7684\u4e2d\u836f\u6ce8\u518c\u5ba1\u8bc4\u8bc1\u636e\u4f53\u7cfb\u6784\u5efa\uff0c\u5728\u56fd\u5bb6\u76f8\u5173\u7ba1\u7406\u90e8\u95e8\u7684\u6574\u4f53\u7edf\u7b79\u90e8\u7f72\u4e0b\uff0c\u7ecf\u5145\u5206\u51dd\u805a\u5b66\u672f\u5171\u8bc6\uff0c2022\u5e74\u76f8\u5173\u90e8\u95e8\u53d1\u5e03\u4e86\u300a\u4e2d\u836f\u6ce8\u518c\u4e13\u95e8\u89c4\u5b9a\uff08\u5f81\u6c42\u610f\u89c1\u7a3f\uff09\u300b\u3001\u300a\u57fa\u4e8e\u4eba\u7528\u7ecf\u9a8c\u7684\u4e2d\u836f\u590d\u65b9\u5236\u5242\u65b0\u836f\u4e34\u5e8a\u7814\u53d1\u6307\u5bfc\u539f\u5219\uff08\u8bd5\u884c\uff09\u300b\u3001\u300a\u57fa\u4e8e\u201c\u4e09\u7ed3\u5408\u201d\u6ce8\u518c\u5ba1\u8bc4\u8bc1\u636e\u4f53\u7cfb\u4e0b\u7684\u6c9f\u901a\u4ea4\u6d41\u6307\u5bfc\u539f\u5219\uff08\u8bd5\u884c\uff09\u300b\u3001\u300a\u57fa\u4e8e\u4eba\u7528\u7ecf\u9a8c\u7684\u4e2d\u836f\u590d\u65b9\u5236\u5242\u65b0\u836f\u836f\u5b66\u7814\u7a76\u6280\u672f\u6307\u5bfc\u539f\u5219\u300b\u7b49\u6587\u4ef6\u548c\u6280\u672f\u6807\u51c6\uff0c\u57fa\u672c\u5f62\u6210\u4e86\u201c\u4e09\u7ed3\u5408\u201d\u4e2d\u836f\u6ce8\u518c\u5ba1\u8bc4\u8bc1\u636e\u4f53\u7cfb\u3002\u7814\u7a76\u8bba\u65872022\u5e74\u53d1\u8868\u4e8e\u300a\u4e2d\u56fd\u4e2d\u836f\u6742\u5fd7\u300b\u7b49\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u4e5d\u3001\u9996\u4e2a\u4e2d\u56fd\u5927\u9646\u836f\u7269\u809d\u635f\u4f24\u4e0d\u826f\u53cd\u5e94\u8c03\u67e5\u62a5\u544a\u53d1\u5e03<\/strong><\/p>\n<p><span style=\"font-family: \u4eff\u5b8b;\">\u00a0 \u00a0 <\/span>\u89e3\u653e\u519b\u603b\u533b\u9662\u7b2c\u4e94\u533b\u5b66\u4e2d\u5fc3\u8096\u5c0f\u6cb3\u6559\u6388\u56e2\u961f\u8054\u5408\u9996\u90fd\u533b\u79d1\u5927\u5b66\u3001\u56fd\u5bb6\u836f\u54c1\u4e0d\u826f\u53cd\u5e94\u76d1\u6d4b\u4e2d\u5fc3\u7b49\u56e2\u961f\uff0c\u57fa\u4e8e\u56fd\u5bb6\u836f\u54c1\u4e0d\u826f\u53cd\u5e94\u76d1\u6d4b\u5927\u6570\u636e\uff0c\u7ed3\u5408\u836f\u6e90\u6027\u809d\u635f\u4f24\u56e0\u679c\u5173\u7cfb\u8bc4\u4ef7\u201c\u6574\u5408\u8bc1\u636e\u94fe\u6cd5\u201d\uff0c\u5b8c\u6210\u4e86\u9996\u4e2a\u4e2d\u56fd\u5927\u9646\u836f\u7269\u6027\u809d\u635f\u4f24\u4e0d\u826f\u53cd\u5e94\u8c03\u67e5\u62a5\u544a\uff0c\u9610\u660e\u4e86\u603b\u4f53\u6d41\u884c\u8d8b\u52bf\uff0c\u6784\u5efa\u4e86\u201c\u4eba\u53e3\u8c31\u201d\u3001\u201c\u836f\u7269\u8c31\u201d\u548c\u201c\u5730\u57df\u8c31\u201d\uff0c\u4e3a\u6211\u56fd\u836f\u7269\u6027\u809d\u635f\u4f24\u7cbe\u51c6\u9632\u63a7\u63d0\u4f9b\u4e86\u7fd4\u5b9e\u53c2\u8003\u6570\u636e\u3002\u7ed3\u679c\u663e\u793a\uff0c\u5728\u5168\u90e8\u836f\u7269\u6027\u809d\u635f\u4f24\u4e0d\u826f\u53cd\u5e94\u4e2d\uff0c\u4e2d\u8349\u836f\u5360\u6bd44.5%\uff0c\u5316\u5b66\u836f\u536094.5%\u3001\u751f\u7269\u836f\u548c\u5176\u4ed6\u53601.0%\uff0c\u8868\u660e\u4e2d\u8349\u836f\u4e0d\u662f\u4e2d\u56fd\u5927\u9646\u836f\u7269\u6027\u809d\u635f\u4f24\u7684\u9996\u8981\u539f\u56e0\u3002\u7814\u7a76\u8bba\u65872022\u5e74\u53d1\u8868\u4e8e<strong><em>Acta Pharm. Sin. B<\/em><\/strong>\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u5341\u3001\u4e2d\u836f\u6cbb\u7597\u7cd6\u5c3f\u75c5\u80be\u810f\u75be\u75c5\u4f18\u52bf\u7279\u8272\u53ca\u4f5c\u7528\u673a\u5236\u9610\u8ff0\u53d6\u5f97\u65b0\u8fdb\u5c55<\/strong><\/p>\n<p><span style=\"font-family: \u4eff\u5b8b;\">\u00a0 \u00a0 <\/span>\u4e2d\u65e5\u53cb\u597d\u533b\u9662\u674e\u5e73\u6559\u6388\u56e2\u961f\u524d\u671f\u901a\u8fc7\u591a\u4e2d\u5fc3\u4e34\u5e8a\u8bd5\u9a8c\u7814\u7a76\u8bc1\u5b9e\uff0c\u7cd6\u80be\u65b9\u5bf9\u7cd6\u5c3f\u75c5\u80be\u75c5\u60a3\u8005\u5177\u6709\u80be\u810f\u4fdd\u62a4\u4f5c\u7528\uff0c\u53ef\u4ee5\u964d\u4f4e\u5c3f\u86cb\u767d\u6392\u6cc4\uff0c\u6539\u5584\u80be\u529f\u80fd\uff0c\u5c24\u5176\u9488\u5bf9\u7cd6\u5c3f\u75c5\u80be\u75c5eGFR\u4e0b\u964d\uff0c\u80be\u529f\u80fd\u8870\u7aed\u5177\u6709\u660e\u663e\u7684\u6cbb\u7597\u4f5c\u7528\uff0c\u5728eGFR&lt;30mL\/min\/ 1.73m<sup>2<\/sup>\u65f6\u4ecd\u7136\u53ef\u4ee5\u4f7f\u7528\uff0c\u5f25\u8865\u4e86\u897f\u836f\u5728\u8fd9\u65b9\u9762\u7684\u6cbb\u7597\u4e0d\u8db3\u30022022\u5e74\u5317\u4eac\u5e02\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u5176\u4e3a\u533b\u7597\u673a\u6784\u4e2d\u836f\u5236\u5242\u3002\u7814\u7a76\u53d1\u73b0\uff0c\u7cd6\u80be\u65b9\u53ef\u51cf\u8f7b\u7cd6\u5c3f\u75c5\u5927\u9f20\u7ed3\u80a0\u4e0a\u76ae\u635f\u4f24\uff0c\u4ece\u800c\u6291\u5236\u7ed3\u80a0\u708e\u75c7\u53ca\u708e\u75c7\u8bf1\u53d1\u7684Cajal\u95f4\u8d28\u7ec6\u80de\u51cb\u4ea1\uff1b\u53ef\u51cf\u8f7b\u4ee3\u8c22\u4ea7\u7269\u7684\u5f02\u5e38\u79ef\u7d2f\u548c\u80a0\u9053\u83cc\u7fa4\u7684\u7d0a\u4e71\uff0c\u901a\u8fc7\u4e0a\u8c03\u5432\u54da\u884d\u751f\u7269\u7b49\u6c28\u57fa\u9178\u6d3b\u6027\u4ee3\u8c22\u4ea7\u7269\u8c03\u8282\u673a\u4f53\u708e\u75c7\u548c\u6c27\u5316\u5e94\u6fc0\uff0c\u8d77\u5230\u80be\u810f\u7684\u4fdd\u62a4\u4f5c\u7528\uff0c\u63ed\u793a\u4e86\u7cd6\u80be\u65b9\u591a\u73af\u8282\u3001\u591a\u9014\u5f84\u4f5c\u7528\u7684\u65b0\u673a\u5236\u3002\u7814\u7a76\u8bba\u65872022\u5e74\u53d1\u8868\u4e8e<strong><em>Front. Pharmacol., Chin. J. Integr. Med.<\/em><\/strong>\u7b49\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u00a0 \u00a0 \u4e3a\u8d2f\u5f7b\u843d\u5b9e\u515a\u7684\u4e8c\u5341\u5927\u7cbe\u795e\u548c\u300a\u4e2d\u5171\u4e2d\u592e \u56fd\u52a1\u9662\u5173\u4e8e\u4fc3\u8fdb\u4e2d\u533b\u836f\u4f20\u627f\u521b\u65b0\u53d1\u5c55\u7684\u610f\u89c1\u300b\uff0c\u5b9a\u671f\u68b3\u7406\u603b\u7ed3\u4e2d\u533b\u836f\u7814\u7a76 [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[77],"tags":[],"_links":{"self":[{"href":"https:\/\/www.cacm.org.cn\/wp-json\/wp\/v2\/posts\/23526"}],"collection":[{"href":"https:\/\/www.cacm.org.cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.cacm.org.cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.cacm.org.cn\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.cacm.org.cn\/wp-json\/wp\/v2\/comments?post=23526"}],"version-history":[{"count":3,"href":"https:\/\/www.cacm.org.cn\/wp-json\/wp\/v2\/posts\/23526\/revisions"}],"predecessor-version":[{"id":23529,"href":"https:\/\/www.cacm.org.cn\/wp-json\/wp\/v2\/posts\/23526\/revisions\/23529"}],"wp:attachment":[{"href":"https:\/\/www.cacm.org.cn\/wp-json\/wp\/v2\/media?parent=23526"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.cacm.org.cn\/wp-json\/wp\/v2\/categories?post=23526"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.cacm.org.cn\/wp-json\/wp\/v2\/tags?post=23526"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}