{"id":4028,"date":"2012-12-26T08:00:00","date_gmt":"2012-12-26T00:00:00","guid":{"rendered":"http:\/\/cacm.weicms.com.cn\/2012\/12\/26\/4028\/"},"modified":"2012-12-26T08:00:00","modified_gmt":"2012-12-26T00:00:00","slug":"%e5%b0%8f%e5%84%bf%e7%b4%ab%e7%99%9c%e6%80%a7%e8%82%be%e7%82%8e%e8%82%be%e5%b0%8f%e7%ae%a1%e5%8a%9f%e8%83%bd%e6%a3%80%e6%b5%8b%e5%92%8c%e8%8d%af%e7%89%a9%e5%b9%b2%e9%a2%84%e7%9a%84%e4%b8%b4%e5%ba%8a","status":"publish","type":"post","link":"https:\/\/www.cacm.org.cn\/2012\/12\/26\/4028\/","title":{"rendered":"\u5c0f\u513f\u7d2b\u765c\u6027\u80be\u708e\u80be\u5c0f\u7ba1\u529f\u80fd\u68c0\u6d4b\u548c\u836f\u7269\u5e72\u9884\u7684\u4e34\u5e8a\u89c2\u5bdf"},"content":{"rendered":"
\u8fc7\u654f\u6027\u7d2b\u765c\u6027\u80be\u708e(Anaphylatic purpura nephritis,APN)\u662f\u7ee7\u53d1\u4e8e\u8fc7\u654f\u6027\u7d2b\u765c\u7684\u80be\u810f\u75c5\uff0c\u662f\u513f\u7ae5\u6700\u5e38\u89c1\u7684\u7ee7\u53d1\u6027\u80be\u75c5\u3002\u80be\u5c0f\u7ba1\u95f4\u8d28\u635f\u5bb3\u7684\u7a0b\u5ea6\u4e0e\u80be\u529f\u80fd\u51cf\u9000\u4e4b\u95f4\u5b58\u5728\u7740\u663e\u8457\u7684\u76f8\u5173\u6027\u3002\u5c3f\u89c6\u9ec4\u9187\u7ed3\u5408\u86cb\u767d(RBP)\u3001\u5c3f\u80f1\u86cb\u767d\u9176\u6291\u5236\u5242C(Cys C)\u53cd\u6620\u8fd1\u7aef\u5c0f\u7ba1\u91cd\u5438\u6536\u529f\u80fd\u53d8\u5316\uff0c\u5c3fN-\u4e59\u9170-\u03b2-D\u6c28\u57fa\u8461\u8404\u7cd6\u82f7\u9176(NAG)\u5219\u53ef\u53cd\u6620\u80be\u5c0f\u7ba1\u7ed3\u6784\u7684\u7834\u574f\uff0c\u662f\u6025\u6027\u635f\u4f24\u7684\u6807\u5fd7\u7269\u3002
1.\u672c\u8bfe\u9898\u63a2\u8ba8\u4e86\u5c3fRBP\u3001Cys C\u548cNAG\u7684\u6d4b\u5b9a\u5728\u5224\u65ad\u5c0f\u513f\u8fc7\u654f\u6027\u7d2b\u765c\u6027\u80be\u708e\u80be\u5c0f\u7ba1-\u95f4\u8d28\u635f\u4f24\u4e2d\u7684\u4e34\u5e8a\u610f\u4e49\u3002\u7ed3\u679c\u63d0\u793a\uff0c\u80be\u5c0f\u7ba1-\u95f4\u8d28\u75c5\u7406\u635f\u4f24\u8d8a\u91cd\uff0c\u5c3f\u4e2dRBP\u3001Cys C\u3001NAG\u7684\u6c34\u5e73\u8d8a\u9ad8\u3002\u5c3fRBP\u3001Cys C\u3001NAG\u4e09\u8005\u8054\u5408\u68c0\u6d4b\u8f83\u5168\u9762\u5730\u53cd\u6620\u80be\u5c0f\u7ba1\u7684\u635f\u4f24\u60c5\u51b5\uff0c\u63d0\u9ad8\u4e34\u5e8a\u65e9\u671f\u8bca\u65ad\u80be\u5c0f\u7ba1\u635f\u4f24\u7684\u9633\u6027\u7387\u3002\u5c24\u5176\u662f\u5728\u4e0d\u80fd\u505a\u80be\u6d3b\u68c0\u7684\u60c5\u51b5\u4e0b\u53ef\u901a\u8fc7\u5c3f\u4e2d\u4e09\u9879\u6307\u6807\u52a8\u6001\u76d1\u6d4bAPN\u60a3\u513f\u80be\u5c0f\u7ba1\u529f\u80fd\u7684\u53d8\u5316\uff0c\u5bf9\u5224\u65ad\u6cbb\u7597\u6548\u679c\u3001\u4f30\u8ba1\u9884\u540e\u5177\u6709\u91cd\u8981\u7684\u610f\u4e49\u3002
2. \u5c06\u8bfe\u9898\u4e2d\u5efa\u7acb\u7684\u68c0\u6d4b\u65b9\u6cd5\u3001\u8bc4\u4ef7\u65b9\u6848\u5e7f\u6cdb\u7528\u4e8e\u4e34\u5e8a\uff0c\u521b\u9020\u4e86\u7ecf\u6d4e\u548c\u793e\u4f1a\u6548\u76ca\u3002\u6839\u636e\u672c\u7814\u7a76\u7684\u90e8\u5206\u7ed3\u679c\uff0c\u4ece2004\u5e74\u81f3\u4eca\u5df2\u5c06\u5c3fNAG\u9176\u5e94\u7528\u4e8e\u4e34\u5e8a\u68c0\u67e5\uff0c\u4f5c\u4e3a\u6cb3\u5357\u4e2d\u533b\u5b66\u9662\u7b2c\u4e00\u9644\u5c5e\u533b\u9662\u513f\u79d1\u5b9e\u9a8c\u5ba4\u7684\u68c0\u6d4b\u9879\u76ee\u3002\u7ecf\u7edf\u8ba12004\uff5e2010\u5e74\u5e73\u5747\u5e74\u6536\u5165\u57287.5\u4e07\u5143\u3002\u53e6\u5916\uff0c\u4e0d\u4ec5\u5728\u80be\u7ec4\u7ec7\u75c5\u7406\u63d0\u793a\u80be\u5c0f\u7ba1-\u95f4\u8d28\u6025\u6027\u75c5\u53d8\u671f\u53ef\u68c0\u6d4b\u5230RBP\u3001Cys C\u3001NAG\u4e09\u9879\u6307\u6807\u7684\u5f02\u5e38\uff0c\u800c\u4e14\u5728\u6025\u6027\u75c5\u53d8\u6301\u7eed\u5b58\u5728\uff0c\u5df2\u51fa\u73b0\u6162\u6027\u75c5\u53d8\u65f6\uff0c\u4e09\u9879\u6307\u6807\u4e2dRBP\/Cr\u3001Cys C\/cr\u867d\u8f83\u6025\u6027\u671f\u6709\u6240\u4e0b\u964d\uff0c\u4f46\u4ecd\u9ad8\u4e8e\u6b63\u5e38\u503c\uff0c\u4e14\u4e0e\u6025\u6027\u75c5\u53d8\u7ec4\u65e0\u663e\u8457\u5dee\u5f02\u3002\u6545\u5728\u4e34\u5e8a\u4e2d\uff0c\u9700\u52a8\u6001\u76d1\u6d4bAPN\u60a3\u513f\u80be\u5c0f\u7ba1\u529f\u80fd\u7684\u53d8\u5316\uff0c\u5bf9\u4e8e\u5224\u65ad\u6cbb\u7597\u6548\u679c\u3001\u4f30\u8ba1\u9884\u540e\u5177\u6709\u91cd\u8981\u610f\u4e49\u3002\u5c3f\u4e2dRBP\u3001Cys C\u7684\u68c0\u6d4b\u4e5f\u5df2\u7ecf\u6210\u4e3a\u6cb3\u5357\u4e2d\u533b\u5b66\u9662\u7b2c\u4e00\u9644\u5c5e\u533b\u9662\u513f\u79d1\u4e34\u5e8a\u7814\u7a76\u68c0\u67e5\u9879\u76ee\u3002
3. \u63d0\u51fa\u4e86\u5c0f\u513f\u7d2b\u765c\u6027\u80be\u708e\u672c\u8bc1\u548c\u6807\u8bc1\u7ed3\u5408\u7684\u8fa9\u8bc1\u5206\u578b\u65b9\u6cd5\uff0c\u6307\u51fa\u8840\u7600\u8fd9\u4e00\u6807\u8bc1\u8d2f\u7a7f\u75c5\u53d8\u59cb\u7ec8\u3002\u5728\u4e2d\u533b\u8fa9\u8bc1\u5206\u578b\u4e2d\u5c06\u8be5\u75c5\u7684\u672c\u8bc1\u5206\u4e3a\u70ed\u4f24\u8840\u7edc\u3001\u809d\u80be\u9634\u865a\u3001\u6c14\u9634\u4e24\u865a\u3001\u813e\u80be\u9633\u865a4\u578b\uff0c\u6807\u8bc1\u5206\u4e3a\u98ce\u70ed\u3001\u70ed\u6bd2\u3001\u6e7f\u70ed\u3001\u6c34\u6e7f\u3001\u8840\u7600\u3001\u6e7f\u6d4a6\u578b\u3002\u672c\u7814\u7a76\u7ed3\u679c\u63d0\u793a\uff1a\u5728\u4e00\u4e2a\u672c\u8bc1\u7684\u57fa\u7840\u4e0a\uff0c\u53ef\u517c\u5939\u4e00\u4e2a\u6216\u4e00\u4e2a\u4ee5\u4e0a\u7684\u6807\u8bc1\u3002\u672c\u8bc1\u4e2d\u70ed\u4f24\u8840\u7edc\u548c\u809d\u80be\u9634\u865a\u578b\u591a\u517c\u5939\u98ce\u70ed\u3001\u6e7f\u70ed\u6807\u8bc1\uff1b\u6c14\u9634\u4e24\u865a\u578b\u548c\u813e\u80be\u9633\u865a\u591a\u517c\u5939\u6e7f\u70ed\u3001\u6c34\u6e7f\u6807\u8bc1\u3002\u8840\u7600\u8fd9\u4e00\u6807\u8bc1\u591a\u8d2f\u7a7f\u75c5\u53d8\u59cb\u7ec8\u3002\u8fd0\u7528\u672c\u8bc1\u4e0e\u6807\u8bc1\u76f8\u7ed3\u5408\u7684\u8fa8\u8bc1\u5206\u578b\u65b9\u6cd5\uff0c\u53ef\u51c6\u786e\u5730\u8fdb\u884c\u8bc1\u578b\u8bca\u65ad\uff0c\u6709\u52a9\u4e8e\u786e\u5b9a\u6cbb\u5219\uff0c\u8fa8\u8bc1\u65bd\u6cbb\u3002
4. \u7814\u7a76\u4e2d\u521b\u7acb\u7684\u51ac\u866b\u590f\u8349\u5236\u5242\u767e\u7075\u80f6\u56ca\u52a0\u6d3b\u8840\u5316\u7600\u836f\u4e09\u4e03\u53c2\u8054\u5408\u6cbb\u7597\uff0c\u4e0e\u5bf9\u7167\u7ec4\u76f8\u6bd4\u663e\u8457\u5730\u964d\u4f4e\u4e86\u5c3fRBP\u3001Cys C\u548cNAG\u7684\u6c34\u5e73\u3002\u8be5\u9632\u6cbb\u80be\u5c0f\u7ba1\u635f\u4f24\u7684\u65b9\u6848\u63d0\u9ad8\u4e86\u5c0f\u513f\u7d2b\u765c\u6027\u80be\u708e\u7684\u4e34\u5e8a\u7597\u6548\uff0c\u5e76\u88ab\u56fd\u5185\u540c\u884c\u4e13\u5bb6\u8ba4\u53ef\u3002
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